JRF (Basic Sciences) Under SERB Funded Project at IIT Mandi: Apply by April 10

 Applications are invited for JRF (Basic Sciences) Under SERB Funded Project at IIT Mandi for the year 2022. The last date of application is 10 April.

Online applications are invited for the post of a Project Associate – (One-JRF) in a SERB funded research project.

Title of the project

Roles for small heat shock proteins in protective protein aggregation and proteome protection.

Project description

Proper maintenance of cellular proteome is essential for cell viability. Protein quality control systems monitor and protect the cellular proteomes. Molecular chaperones or heat shock proteins (HSPs) play important roles in maintaining and protecting the cellular protein homeostasis (proteostasis).

Failure to maintain it result in protein misfolding and aggregation, which is a hallmark for number of age-related diseases. Small HSPs are ATPindependent chaperones which are induced by heat shock and other stresses to protect cells.

They are implicated in regulating a large number of fundamental cellular processes and are involved in many pathological diseases including aging. It has been reported that small HSPs are involved in regulating the life span and their abundance levels increase during aging.

Specific small HSPs are enriched in the insoluble proteome, implying their involvement in protective aggregation response during aging. Whether it is co-aggregation or active sequestration as a protective strategy and their functional relevance is remained to be identified.

Aim of this project is to characterize novel functions of small HSPs as protectors of proteome and connection to protein quality control pathways using C. elegans as a model organism.

Eligibility

MSc / MTech in related branch of life Sciences with 60% marks or equivalent CGPA. Candidates with NET/GATE qualification and/or experience in working with model organisms, molecular biology and biochemical methods will be given preference in shortlisting for interview.

Fellowship

Maximum Rs. 31,000/- per month as per guidelines (subject to fulfilling eligibility criteria).

Duration

Initially for one year with possibility of extension up to 3 years. The position may be converted to a full time Ph.D. position, subject to fulfilling eligibility criteria and satisfactory performance.

Application

Interested and eligible candidates may apply with an updated resume (in PDF file) mentioning personal details and academic qualifications with the file name “First name_Last name” and email to prasadkasturi[at]iitmandi.ac.in (The subject line of the email should be ‘Application for the post of project associate’). The candidate should clearly mention the details about NET/GATE qualification (Year, rank, score etc.) and work experience, if they have, in the resume.

Deadline

Last date of resume submission: 10th April 2022.

Click here to view the official notification of JRF (Basic Sciences) Under SERB Funded Project at IIT Mandi.